“Regenerative” is one of the most overused words in aesthetics right now. Plant-derived exosomes. Next-generation PRP. Autologous biofiller. Device-assisted delivery. The category is moving fast, but so is the marketing, and the two are not always the same thing.
Clinic owners are focusing on building a credible regenerative offering, so they need clarity on what’s worth adding to their menu, the supporting evidence, and how these modalities work together in practice.
Explore regenerative Aesthetics & Biologics for Clinics
What Does “Regenerative Aesthetics” Actually Mean?
Regenerative aesthetics refers to treatments that support or stimulate the body’s own repair and renewal processes. The aim is to encourage the skin to act like younger skin. This means improving your skin’s collagen and elastin production, improving its structural integrity, and remodelling over time.
This is different from traditional injectable fillers or superficial skin treatments. When chosen carefully and used appropriately, regenerative approaches can produce visible, durable improvements in skin quality, texture, and appearance.
Plant-Derived Extracellular Nanoparticles
The term “exosome” has become common in aesthetics marketing, but precision matters here.
Exosomes are small extracellular vesicles released by cells that act as biological messengers, carrying signals involved in repair, immune response, and regeneration. Human-derived exosomes remain tightly regulated in the UK, and products claiming to contain them carry significant compliance considerations.
The more accessible and clinically interesting category is plant-derived extracellular nanoparticles (PDENs), sometimes described as the plant equivalent of human exosomes.
PDENs are nano-sized vesicles produced during processes of plant cell activation. They carry a naturally occurring payload of growth factors, peptides, amino acids, proteins, and liposomes that can interact with human skin cells and support regeneration through biomimetic signalling.
Research into PDENs is relatively early but growing. Peer-reviewed studies and reviews of plant-derived extracellular vesicles, often described as exosome-like nanovesicles, suggest anti-inflammatory activity and potential roles in tissue repair in preclinical settings. This includes dermatology-focused discussion in the Journal of Nanobiotechnology, a chronic wound healing review in the International Journal of Nanomedicine, mechanistic work linking vesicles to angiogenesis in ACS Applied Materials & Interfaces, and earlier anti-inflammatory research published in Biomaterials. They work topically or via assisted transdermal delivery. The mechanism is one of supporting the skin’s natural signalling environment, not introducing cellular material.
EXO|E is AMP’s professional skin revitalising complex, built around plant stem cell technology and a PDEN-containing formulation called CF-a1. It’s chemical-free, water-based, and designed for use alongside aesthetic procedures.
The three-step protocol covers pre-treatment preparation (D|TOX), in-clinic application (EXO|E concentrate), and post-procedure recovery (RE|PAIR). This gives clinics a structured, repeatable patient journey that supports outcomes and reduces downtime.
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PRP in Aesthetics
Platelet-Rich Plasma is one of the more established biologic treatments in aesthetics. A small volume of the patient’s blood is centrifuged to isolate a platelet-rich fraction, which is then reintroduced to the treatment area. Platelets carry growth factors, including PDGF, TGF-beta, and VEGF, that support tissue repair, collagen synthesis, and new blood vessel formation.
The evidence base is most consistent in three areas: skin quality improvement, hair restoration, and adjunctive use alongside device-based treatments. PRP is not, in the main, a volumising treatment, and managing patient expectations on this point matters.
Consistency is one of the more significant clinical challenges with PRP. Platelet yield varies between patients and between systems. The preparation method, including centrifuge speed, time, tube type, and separation technology, directly affects the output. The system you choose is as clinically significant as the protocol you follow.
Cellenis PRP addresses this through a specialist gel-separator tube that is intended to minimise red blood cell contamination in the PRP fraction; the manufacturer describes this as almost complete RBC elimination.” Virtually all red blood cells are removed, and inflammatory white blood cells are significantly reduced in a single centrifuge spin. The simplified three-step workflow (collect, extract, treat) supports consistency across practitioners and patient visits, which matters for both clinical outcomes and patient confidence.
“Using a gel-separator tube, the system is intended to minimise red blood cell contamination in the PRP fraction; the manufacturer describes this as almost complete RBC elimination.”
https://www.cellenis.com/cellenis-prp/
Cellenis PRP is most commonly used in UK clinics for facial skin quality protocols, scalp and hair restoration programmes, neck and décolletage treatments.
About Cellenis® PRP
Autologous Biofiller
Autologous biofiller, sometimes called platelet-rich dermafiller, represents a natural development of PRP technology. Rather than using the platelet-rich plasma fraction alone, this approach processes the platelet-poor plasma (PPP) component to create a gel-like injectable that provides immediate volumising alongside long-term regenerative benefit.
Cellenis DermaFiller works by heating the PPP fraction to restructure its albumin proteins, producing a natural injectable gel derived entirely from the patient’s own blood. The result is dual-action: an immediate soft volumising effect (results typically last three to six months) combined with ongoing stimulation of collagen, fibrin, and elastin production beneath the surface.
Because Cellenis DermaFiller is autologous, there is no risk of allergic reaction or immune response. It is naturally biocompatible, and the regenerative benefit continues after the initial volumising effect diminishes.
Cellenis DermaFiller is not a direct replacement for hyaluronic acid fillers. It produces a softer, more diffuse effect and suits patients looking for natural-looking improvement.
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Combining Biologics with Energy-Based Devices
The relationship between biologics and energy-based devices is not just additive. In many cases, it is genuinely synergistic. Devices that create controlled micro-injury or thermal remodelling generate a healing cascade in the skin. Introducing biologics at the right point in that cascade can amplify the response, improve outcomes, and shorten recovery.
There are four combination protocols clinics can apply regularly:
1. Pre-treatment skin preparation
EXO|E’s D|TOX step is designed for this purpose and is applied by the patient for 7 days before treatment to reduce baseline inflammation and improve skin receptivity.
2. Concurrent application
Following microneedling, RF microneedling, or fractional treatment, applying EXO|E’s in-clinic concentrate allows active components to reach the dermis more effectively than through intact skin.
The ULTRA+ device from AMP is specifically designed to work alongside EXO|E, combining ultrasound, radiofrequency, and EMS with structured serum delivery as part of a controlled facial or scalp protocol. This extends the clinical value of a device treatment into the healing window. The RE|PAIR step within the EXO|E protocol supports barrier restoration, reduces inflammation, and sustains the regenerative signal during recovery.
Discover the ULTRA+3. Post-procedure recovery support
4. PRP as post-device
PRP works particularly well following treatments that generate a wound response, including fractional laser and RF microneedling.
Applying Cellenis PRP after these procedures introduces growth factors at the point when the skin’s repair mechanisms are most active, supporting collagen formation and reducing downtime.
The same principle applies in hair restoration, where Cellenis PRP is regularly combined with scalp-focused device treatment.
Practical Considerations for Clinics
Consent and contraindications: Biologic treatments involving blood draw require practitioners to be appropriately trained, with full medical history review, contraindication screening, and written consent in place. Key contraindications for PRP include active blood or platelet disorders, anticoagulant therapy, active infection, and immunocompromised status. Always refer to manufacturer guidance for each product.
Storage and handling: EXO|E products require temperature-controlled storage conditions. PRP must be processed and used within specified timeframes once prepared. These are not optional steps; they affect both patient safety and treatment outcomes and should be embedded in your clinic SOPs from the outset.
Staff training: Understanding the technical preparation of a biologic treatment is only part of what practitioners need. Explaining the treatment clearly, managing patient expectations, and handling post-treatment queries consistently are equally important for retention and reputation. AMP provides training and protocol support as part of its partnership with clinics, not as an add-on.
Setting patient expectations: Regenerative treatments typically require two or more sessions before optimal results are visible. Clinics that package and communicate this clearly retain patients. Clinics that imply faster or more dramatic outcomes lose them. Accurate expectation management is both a clinical responsibility and a commercial one.
Always consult appropriate clinical guidance and manufacturer protocols when designing regenerative treatment pathways. Practitioners should assess individual patient suitability before recommending any procedure.
Building a Regenerative Offering That Delivers
Regenerative aesthetics is a genuinely exciting area, but its clinical credibility depends on the choices clinics make: which products they select, how they combine them, and how clearly they communicate what patients can expect.
Plant-derived extracellular nanoparticles, PRP, and autologous biofiller each bring distinct mechanisms and benefits. Used thoughtfully alongside energy-based devices, they can meaningfully improve outcomes rather than simply adding cost to a protocol.
The clinics that will build lasting reputations in this space are those that prioritise evidence, consistency, and honest patient conversations over trend-chasing. The technology is there. The differentiation lies in how well you apply it.